Actinonin
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Preferred IUPAC name (2R)-N4-Hydroxy-N1-{(2S)-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-pentylbutanediamide | |
Other names HONH-Val-Pro-OH (IUPAC peptide linear) | |
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Properties | |
Chemical formula | C19H35N3O5 |
Molar mass | 385.505 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Chemical compound
Actinonin is a naturally occurring antibacterial agent that has demonstrated anti-tumor activity.[1]
Actiononin has been shown to inhibit the enzyme peptide deformylase, which is essential in bacteria.[2]
References
- ^ Chen, D.Z.; Patel, D.V. (2000). "Actinonin, a Naturally Occurring Antibacterial Agent, Is a Potent Deformylase Inhibitor". Biochemistry. 39 (6): 1256–62. doi:10.1021/bi992245y. PMID 10684604.
- ^ Yoon, Hye-Jin; Kim, Hye Lee; Lee, Soo-Kyoung; Kim, Hyun-Woo; Kim, Hyung-Wook; Lee, Jae Young; Mikami, Bunzo; Suh, Se Won (2004). "Crystal structure of peptide deformylase from Staphylococcus aureus in complex with actinonin, a naturally occurring antibacterial agent". Proteins: Structure, Function, and Bioinformatics. 57 (3): 639–642. doi:10.1002/prot.20231. ISSN 1097-0134. PMID 15382235. S2CID 42929776.
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