DVL3

Protein-coding gene in the species Homo sapiens

DVL3

Identifiers

Aliases

DVL3, DRS3, dishevelled segment polarity protein 3

External IDs

OMIM: 601368; MGI: 108100; HomoloGene: 20928; GeneCards: DVL3; OMA:DVL3 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q27.1	Start	184,155,377 bp^[1]
Band	3q27.1	End	184,173,614 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16 A3\|16 12.46 cM	Start	20,335,732 bp^[2]
Band	16 A3\|16 12.46 cM	End	20,352,760 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

stromal cell of endometrium

ganglionic eminence

gastric mucosa

muscle layer of sigmoid colon

body of uterus

apex of heart

sural nerve

right ovary

left uterine tube

left ovary

Top expressed in

cardiac muscle tissue of left ventricle

external carotid artery

internal carotid artery

genital tubercle

choroid plexus of fourth ventricle

trigeminal ganglion

tail of embryo

molar

ventricular zone

zygote

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	beta-catenin binding frizzled binding protease binding protein binding protein heterodimerization activity signaling receptor binding
Cellular component	cytoplasm cytosol
Biological process	positive regulation of protein phosphorylation intracellular signal transduction positive regulation of JUN kinase activity protein stabilization Wnt signaling pathway positive regulation of transcription, DNA-templated multicellular organism development positive regulation of GTPase activity negative regulation of canonical Wnt signaling pathway beta-catenin destruction complex disassembly non-canonical Wnt signaling pathway non-canonical Wnt signaling pathway via JNK cascade canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway planar cell polarity pathway involved in neural tube closure positive regulation of neuron projection arborization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1857


13544

Ensembl


ENSG00000161202


ENSMUSG00000003233

UniProt


Q92997


Q61062

RefSeq (mRNA)


NM_004423


NM_007889 NM_001347176

RefSeq (protein)


NP_004414


NP_001334105 NP_031915

Location (UCSC)

Chr 3: 184.16 – 184.17 Mb

Chr 16: 20.34 – 20.35 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Segment polarity protein dishevelled homolog DVL-3 is a protein that in humans is encoded by the DVL3 gene.^[5]^[6]

This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.^[6]

Interactions

DVL3 has been shown to interact with DAB2,^[7] DVL1^[8] and PRPF3.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161202 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003233 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, Giardino L, Ratti A, Penso D, Calza L, Palka G, Scarlato G, Novelli G, Dallapiccola B (January 1997). "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene". Hum Mol Genet. 5 (7): 953–958. doi:10.1093/hmg/5.7.953. PMID 8817329.
^ ^a ^b "Entrez Gene: DVL3 dishevelled, dsh homolog 3 (Drosophila)".
^ Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. 22 (12). England: 3084–3094. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138. PMID 12805222.
^ Kishida, S; Yamamoto H; Hino S; Ikeda S; Kishida M; Kikuchi A (June 1999). "DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability". Mol. Cell. Biol. 19 (6). UNITED STATES: 4414–4422. doi:10.1128/mcb.19.6.4414. ISSN 0270-7306. PMC 104400. PMID 10330181.
^ Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). England: 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–329, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
Semënov MV, Snyder M (1997). "Human dishevelled genes constitute a DHR-containing multigene family". Genomics. 42 (2): 302–310. doi:10.1006/geno.1997.4713. PMID 9192851.
Bui TD, Beier DR, Jonssen M, et al. (1997). "cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas". Biochem. Biophys. Res. Commun. 239 (2): 510–516. doi:10.1006/bbrc.1997.7500. PMID 9344861.
Kishida S, Yamamoto H, Hino S, et al. (1999). "DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability". Mol. Cell. Biol. 19 (6): 4414–4422. doi:10.1128/mcb.19.6.4414. PMC 104400. PMID 10330181.
Song DH, Sussman DJ, Seldin DC (2000). "Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells". J. Biol. Chem. 275 (31): 23790–23797. doi:10.1074/jbc.M909107199. PMID 10806215.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hocevar BA, Mou F, Rennolds JL, et al. (2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. 22 (12): 3084–3094. doi:10.1093/emboj/cdg286. PMC 162138. PMID 12805222.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Torban E, Wang HJ, Groulx N, Gros P (2005). "Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family". J. Biol. Chem. 279 (50): 52703–52713. doi:10.1074/jbc.M408675200. PMID 15456783.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Chan DW, Chan CY, Yam JW, et al. (2006). "Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer". Gastroenterology. 131 (4): 1218–1227. doi:10.1053/j.gastro.2006.07.020. PMID 17030191.