Gastrokine-1

Protein-coding gene in the species Homo sapiens
GKN1
Identifiers
AliasesGKN1, AMP18, BRICD1, CA11, FOV, foveolin, gastrokine 1
External IDsOMIM: 606402; MGI: 1913533; HomoloGene: 10487; GeneCards: GKN1; OMA:GKN1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for GKN1
Genomic location for GKN1
Band2p13.3Start68,974,573 bp[1]
End68,980,980 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for GKN1
Genomic location for GKN1
Band6|6 D1Start87,322,632 bp[2]
End87,327,924 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastric mucosa

  • pylorus

  • cardia

  • mucosa of ileum

  • body of stomach

  • fundus

  • decidua

  • left adrenal gland

  • right adrenal cortex

  • left adrenal cortex
Top expressed in
  • epithelium of stomach

  • mucous cell of stomach

  • pyloric antrum

  • duodenum

  • interventricular septum

  • esophagus

  • decidua

  • cornea

  • jejunum

  • islet of Langerhans
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • molecular function
Cellular component
  • extracellular region
  • extracellular space
  • cellular component
Biological process
  • digestion
  • positive regulation of cell division
  • regulation of cell population proliferation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56287

66283

Ensembl

ENSG00000169605

ENSMUSG00000030050

UniProt

Q9NS71

Q9CR36

RefSeq (mRNA)

NM_019617

NM_025466

RefSeq (protein)

NP_062563

NP_079742

Location (UCSC)Chr 2: 68.97 – 68.98 MbChr 6: 87.32 – 87.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gastrokine-1 is a protein that in humans is encoded by the GKN1 gene.[5][6][7]

The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169605 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030050 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Martin TE, Powell CT, Wang Z, Bhattacharyya S, Walsh-Reitz MM, Agarwal K, Toback FG (August 2003). "A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa" (PDF). American Journal of Physiology. Gastrointestinal and Liver Physiology. 285 (2): G332-43. doi:10.1152/ajpgi.00453.2002. PMID 12851218. S2CID 2860022. Archived from the original (PDF) on 2019-03-02.
  6. ^ Shiozaki K, Nakamori S, Tsujie M, Okami J, Yamamoto H, Nagano H, et al. (October 2001). "Human stomach-specific gene, CA11, is down-regulated in gastric cancer". International Journal of Oncology. 19 (4): 701–7. doi:10.3892/ijo.19.4.701. PMID 11562744.
  7. ^ a b "Entrez Gene: GKN1 gastrokine 1".

Further reading

  • Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I (May 2000). "Isolation of two novel genes, down-regulated in gastric cancer". Japanese Journal of Cancer Research. 91 (5): 459–63. doi:10.1111/j.1349-7006.2000.tb00967.x. PMC 5926377. PMID 10835488.
  • Westley BR, Griffin SM, May FE (June 2005). "Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C". Biochemistry. 44 (22): 7967–75. doi:10.1021/bi047287n. PMID 15924415.
  • Walsh-Reitz MM, Huang EF, Musch MW, Chang EB, Martin TE, Kartha S, Toback FG (July 2005). "AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins". American Journal of Physiology. Gastrointestinal and Liver Physiology. 289 (1): G163-71. doi:10.1152/ajpgi.00013.2005. PMC 1444946. PMID 15961882.
  • Nardone G, Rippa E, Martin G, Rocco A, Siciliano RA, Fiengo A, et al. (February 2007). "Gastrokine 1 expression in patients with and without Helicobacter pylori infection". Digestive and Liver Disease. 39 (2): 122–9. doi:10.1016/j.dld.2006.09.017. PMID 17092786.
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