GH1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/d/df/Protein_GH1_PDB_1a22.png/250px-Protein_GH1_PDB_1a22.png) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1AXI, 1HUW, 1A22, 1HGU, 3HHR, 1KF9, 1HWG, 1BP3, 1HWH |
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Identifiers |
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Aliases | GH1, GH, GH-N, GHN, IGHD1B, hGH-N, GHB5, Growth hormone 1, IGHD2, IGHD1A |
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External IDs | OMIM: 139250; MGI: 95707; HomoloGene: 128036; GeneCards: GH1; OMA:GH1 - orthologs |
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Gene location (Human) |
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![Chromosome 17 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/300px-Ideogram_human_chromosome_17.svg.png) | Chr. | Chromosome 17 (human)[1] |
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| Band | 17q23.3 | Start | 63,917,200 bp[1] |
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End | 63,918,839 bp[1] |
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Gene location (Mouse) |
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![Chromosome 11 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/260px-Ideogram_house_mouse_chromosome_11.svg.png) | Chr. | Chromosome 11 (mouse)[2] |
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| Band | 11 E1|11 68.89 cM | Start | 106,191,097 bp[2] |
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End | 106,192,691 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - pituitary gland
- anterior pituitary
- testicle
- granulocyte
- right coronary artery
- gastric mucosa
- right hemisphere of cerebellum
- right uterine tube
- Descending thoracic aorta
- canal of the cervix
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| Top expressed in | - pituitary gland
- morula
- anterior pituitary
- entorhinal cortex
- perirhinal cortex
- fetal liver hematopoietic progenitor cell
- Epithelium of choroid plexus
- epithelium of small intestine
- nucleus of stria terminalis
- choroid plexus of fourth ventricle
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/b/b0/PBB_GE_GH1_205840_x_at_fs.png/250px-PBB_GE_GH1_205840_x_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/3/32/PBB_GE_GH1_206885_x_at_fs.png/250px-PBB_GE_GH1_206885_x_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/5/51/PBB_GE_GH1_206886_x_at_fs.png/250px-PBB_GE_GH1_206886_x_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - hormone activity
- metal ion binding
- protein binding
- growth factor activity
- growth hormone receptor binding
- prolactin receptor binding
| Cellular component | - extracellular region
- extracellular space
- endosome lumen
- growth hormone receptor complex
- collagen-containing extracellular matrix
| Biological process | - growth hormone receptor signaling pathway via JAK-STAT
- response to estradiol
- positive regulation of MAP kinase activity
- positive regulation of receptor internalization
- bone maturation
- growth hormone receptor signaling pathway
- positive regulation of insulin-like growth factor receptor signaling pathway
- positive regulation of multicellular organism growth
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of phosphatidylinositol 3-kinase signaling
- positive regulation of receptor signaling pathway via JAK-STAT
- positive regulation of activation of Janus kinase activity
- positive regulation of tyrosine phosphorylation of STAT protein
- regulation of signaling receptor activity
- positive regulation of glucose transmembrane transport
- response to nutrient levels
- positive regulation of growth
- animal organ development
- signal transduction
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_000515 NM_022559 NM_022560 NM_022561 NM_022562 |
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RefSeq (protein) | |
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NP_000506 NP_072053 NP_072054 |
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Location (UCSC) | Chr 17: 63.92 – 63.92 Mb | Chr 11: 106.19 – 106.19 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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