Kyotorphin
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IUPAC name (2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-5- (diaminomethylideneamino)pentanoic acid | |
Other names Kiotorphin L-Tyrosyl-L-arginine | |
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Properties | |
Chemical formula | C15H23N5O4 |
Molar mass | 337.380 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Chemical compound
Kyotorphin (L-tyrosyl-L-arginine) is a neuroactive dipeptide which plays a role in pain regulation in the brain. It was first isolated from bovine brain, by Japanese scientists in 1979.[1] Kyotorphin was named for the site of its discovery, Kyoto, Japan and because of its morphine- (or endorphin-) like analgesic activity. Kyotorphin has an analgesic effect, but it does not interact with the opioid receptors. Instead, it acts by releasing met-enkephalin and stabilizing it from degradation. It may also possess properties of neuromediator/neuromodulator. It has been shown that kyotorphin is present in the human cerebrospinal fluid and that its concentration is lower in patients with persistent pain.[2]
References
- ^ Takagi H, Shiomi H, Ueda H, Amano H (November 1979). "A novel analgesic dipeptide from bovine brain is a possible Met-enkephalin releaser". Nature. 282 (5737): 410–2. doi:10.1038/282410a0. PMID 228202.
- ^ Nishimura K, Kaya K, Hazato T, Ueda H, Satoh M, Takagi H (November 1991). "[Kyotorphin like substance in human cerebrospinal fluid of patients with persistent pain]". Masui (in Japanese). 40 (11): 1686–90. PMID 1766121.
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- Enkephalinase inhibitors: Amastatin
- BL-2401
- Candoxatril
- D -Phenylalanine
- Dexecadotril (retorphan)
- Ecadotril (sinorphan)
- Kelatorphan
- Racecadotril (acetorphan)
- RB-101
- RB-120
- RB-3007
- Opiorphan
- Selank
- Semax
- Spinorphin
- Thiorphan
- Tynorphin
- Ubenimex (bestatin)
- Propeptides: β-Lipotropin (proendorphin)
- Prodynorphin
- Proenkephalin
- Pronociceptin
- Proopiomelanocortin (POMC)
- Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)