Picoplatin

Picoplatin
Names
IUPAC name
azane; 2-methylpyridine; platinum(2+); dichloride
Identifiers
CAS Number
  • 181630-15-9 checkY
3D model (JSmol)
  • ionic form: Interactive image
  • coordination form: Interactive image
ChemSpider
  • 154428 ☒N
ECHA InfoCard 100.205.233 Edit this at Wikidata
PubChem CID
  • 177358
UNII
  • B5TAN0L720 checkY
CompTox Dashboard (EPA)
  • DTXSID10939458 Edit this at Wikidata
InChI
  • InChI=1S/C6H7N.2ClH.H3N.Pt/c1-6-4-2-3-5-7-6;;;;/h2-5H,1H3;2*1H;1H3;/q;;;;+2/p-2 ☒N
    Key: IIMIOEBMYPRQGU-UHFFFAOYSA-L ☒N
  • InChI=1/C6H7N.2ClH.H3N.Pt/c1-6-4-2-3-5-7-6;;;;/h2-5H,1H3;2*1H;1H3;/q;;;;+2/p-2
    Key: IIMIOEBMYPRQGU-NUQVWONBAG
  • ionic form: Cc1ccccn1.N.[Cl-].[Cl-].[Pt+2]
  • coordination form: Cl[Pt-2](Cl)([NH3+])[n+]1ccccc1C
Properties
Chemical formula
 C6H10Cl2N2Pt
Molar mass 376.14 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references
Chemical compound

Picoplatin is a platinum-based antineoplastic agent in clinical development by Poniard Pharmaceuticals (previously NeoRx) for the treatment of patients with solid tumors.[1]

In Phase I and Phase II clinical trials, picoplatin demonstrated activity in a variety of solid tumors, including lung, ovarian, colorectal and hormone-refractory prostate cancer.[2] However, in Phase III trials, picoplatin failed to hit its primary endpoint for advanced small cell lung cancer.[3] Hopes are now pinned on its use for metastatic colorectal cancer.[4]

References

  1. ^ Wheate, Nial J. (2010). "The status of platinum anticancer drugs in the clinic and in clinical trials" (PDF). Dalton Transactions. 39 (35): 8113–8127. doi:10.1039/C0DT00292E. hdl:2123/14271. PMID 20593091.
  2. ^ Picoplatin Clinical Results, Poniard Pharmaceuticals
  3. ^ Poniard shares crash on Phase III picoplatin failure, fiercebiotech.com, November 16, 2009
  4. ^ http://www.genengnews.com/specialreports/sritem.aspx?oid=69418732 Nov 2009
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Platinum compounds
Pt(-II)
  • Cs2Pt
Pt(0)
  • Pt(PPh3)4
Pt(II)
  • Pt(NH3)2(CO2)2C4H6
  • cis-Pt(NH3)2Cl2
  • trans-Pt(NH3)2Cl2
  • K2Pt(CN)4
  • Pt(NH3)4PtCl4
  • Pt(NH3)2CO2CH2O
  • (Cy(NH2)2)PtC2O4
  • NH3PtCl2(PyrMe)
  • Pt(OAc)2
  • PtBr2
  • PtCl2
  • PtF2
  • PtI
    2
  • PtP2
  • K2PtCl4
  • [(PtCl(NH3)2(C6H12(NH2)2))Pt(NH3)2](NO3)4
  • Pt(OH)2
  • PtSm
  • Pt(C5H7O2)2
  • PtS
Organoplatinum(II) compounds
  • PtCl2(Cod)
  • Pt(CNO)2
  • KPtCl3C2H4
    • Pt(IV)
    • PtO2
    • (NH4)2PtCl6
    • H2PtCl6
    • PtBr4
    • PtCl4
    • PtF4
    • K2PtCl6
    • Pt(OAc)2Cl2(NH3)(NH2Cy)
    • Na2PtCl6
    • Pt(OH)4
    • PtI4
    • PtS2
    • PtSe2
    Pt(V)
    • PtF5
    • O2PtF6
    • XePtF6
    Pt(VI)
    • PtF6


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