Protein BEX1

Protein-coding gene in the species Homo sapiens
BEX1
Identifiers
AliasesBEX1, BEX2, HBEX2, HGR74-h, brain expressed X-linked 1
External IDsOMIM: 300690 MGI: 1338017 HomoloGene: 135613 GeneCards: BEX1
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for BEX1
Genomic location for BEX1
BandXq22.1|Xq22Start103,062,651 bp[1]
End103,064,171 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for BEX1
Genomic location for BEX1
BandX F1|X 57.37 cMStart134,967,313 bp[2]
End134,968,985 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • Brodmann area 23

  • middle temporal gyrus

  • orbitofrontal cortex

  • dorsolateral prefrontal cortex

  • superior frontal gyrus

  • Brodmann area 9

  • prefrontal cortex

  • pituitary gland

  • anterior pituitary
Top expressed in
  • arcuate nucleus

  • ventromedial nucleus

  • paraventricular nucleus of hypothalamus

  • temporal lobe

  • amygdala

  • dorsomedial hypothalamic nucleus

  • lateral hypothalamus

  • median eminence

  • medial ganglionic eminence

  • nucleus accumbens
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • nucleus
  • transcription regulator complex
Biological process
  • multicellular organism development
  • cell differentiation
  • positive regulation of DNA-binding transcription factor activity
  • nervous system development
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55859

12069

Ensembl

ENSG00000133169

ENSMUSG00000042750

UniProt

Q9HBH7

Q9WTZ8

RefSeq (mRNA)

NM_018476

NM_009749

RefSeq (protein)

NP_060946

NP_033879

Location (UCSC)Chr X: 103.06 – 103.06 MbChr X: 134.97 – 134.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein BEX1 also known as brain-expressed X-linked protein 1 is a protein that in humans is encoded by the BEX1 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133169 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042750 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: BEX1 brain expressed, X-linked 1".

Further reading

  • Foltz G, Ryu GY, Yoon JG, et al. (2006). "Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma". Cancer Res. 66 (13): 6665–74. doi:10.1158/0008-5472.CAN-05-4453. PMID 16818640.
  • Alvarez E, Zhou W, Witta SE, Freed CR (2005). "Characterization of the Bex gene family in humans, mice, and rats". Gene. 357 (1): 18–28. doi:10.1016/j.gene.2005.05.012. PMID 15958283.
  • Quentmeier H, Tonelli R, Geffers R, et al. (2005). "Expression of BEX1 in acute myeloid leukemia with MLL rearrangements". Leukemia. 19 (8): 1488–9. doi:10.1038/sj.leu.2403820. PMID 15920485.
  • Baldisseri DM, Margolis JW, Weber DJ, et al. (2002). "Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction". J. Mol. Biol. 319 (3): 823–37. doi:10.1016/S0022-2836(02)00282-6. PMID 12054873.
  • Yang QS, Xia F, Gu SH, et al. (2002). "Cloning and expression pattern of a spermatogenesis-related gene, BEX1, mapped to chromosome Xq22". Biochem. Genet. 40 (1–2): 1–12. doi:10.1023/A:1014565320998. PMID 11989783. S2CID 24146602.


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