Protein-coding gene in the species Homo sapiens
| ST8SIA6 |
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| Identifiers |
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| Aliases | ST8SIA6, SIA8F, SIAT8F, ST8SIA-VI, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6, ST8SiaVI, SIAT8-F |
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| External IDs | OMIM: 610139; MGI: 2386797; HomoloGene: 17112; GeneCards: ST8SIA6; OMA:ST8SIA6 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 10 (human)[1] |
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| | Band | 10p12.33 | Start | 17,315,421 bp[1] |
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| End | 17,454,595 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 2 (mouse)[2] |
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| | Band | 2|2 A1 | Start | 13,655,832 bp[2] |
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| End | 13,798,875 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - testicle
- gonad
- substantia nigra
- apex of heart
- left ventricle
- right auricle
- epithelium of colon
- lung
- thymus
- white blood cell
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| | Top expressed in | - conjunctival fornix
- transitional epithelium of urinary bladder
- substantia nigra
- epithelium of stomach
- hair follicle
- cornea
- lateral septal nucleus
- lacrimal gland
- ciliary body
- lumbar subsegment of spinal cord
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - transferase activity
- sialyltransferase activity
- glycosyltransferase activity
- alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
| | Cellular component | - integral component of membrane
- Golgi membrane
- Golgi apparatus
- membrane
| | Biological process | - glycolipid biosynthetic process
- sialylation
- protein glycosylation
- protein O-linked glycosylation
- glycoprotein metabolic process
- oligosaccharide metabolic process
- ganglioside biosynthetic process
- carbohydrate biosynthetic process
- blastocyst hatching
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 10: 17.32 – 17.45 Mb | Chr 2: 13.66 – 13.8 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 is a protein that in humans is encoded by the ST8SIA6 gene. [5]
Function
Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 2.4.99.8) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000148488 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003418 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6". Retrieved 2017-02-02.
Further reading
- Avril T, North SJ, Haslam SM, Willison HJ, Crocker PR (2006). "Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression". J. Leukoc. Biol. 80 (4): 787–96. doi:10.1189/jlb.1005559. PMID 16857734. S2CID 7578193.
- Szabo R, Skropeta D, et al. (2017). "Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities". Med. Res. Rev. 37 (2): 210–270. doi:10.1002/med.21407. PMID 27678392. S2CID 26280291.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
