Trolnitrate

Trolnitrate
Names
IUPAC name
2-[bis(2-nitrooxyethyl)amino]ethyl nitrate
Identifiers
CAS Number
  • 7077-34-1 ☒N
3D model (JSmol)
  • Interactive image
ChemSpider
  • 11015 checkY
ECHA InfoCard 100.027.615 Edit this at Wikidata
PubChem CID
  • 11499
UNII
  • B9M85U075P checkY
CompTox Dashboard (EPA)
  • DTXSID7023722 Edit this at Wikidata
InChI
  • InChI=1S/C6H12N4O9/c11-8(12)17-4-1-7(2-5-18-9(13)14)3-6-19-10(15)16/h1-6H2 checkY
    Key: HWKQNAWCHQMZHK-UHFFFAOYSA-N checkY
  • C(CO[N+](=O)[O-])N(CCO[N+](=O)[O-])CCO[N+](=O)[O-]
Properties
Chemical formula
C6H12N4O9
Molar mass 284.18 g/mol
Pharmacology
C01DA09 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound

Trolnitrate (triethanolamine trinitrate, commonly used in the form of biphosphate salt also known as metamine) is an organic nitrate with vasodilator activity that is used to prevent or ameliorate attacks of angina pectoris.[1] Trolnitrate dilates the coronary vessels because of its basic action as a smooth muscle depressant, just as do nitroglycerin and other organic nitrates.[2]

References

  1. ^ "Medical Definition of TROLNITRATE".
  2. ^ "NCATS Inxight Drugs — TROLNITRATE".


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Forms
  • Nitroxyl anion (NO; oxonitrate(1-), hyponitrite anion)
  • Nitric oxide (NO; nitrogen monoxide)
  • Nitrosonium (NO+; nitrosyl cation)
Targets
sGC
  • Inhibitors: ODQ
NO donors
(prodrugs)
  • NONOates (diazeniumdiolates): Diethylamine/NO (DEA/NO)
  • Diethylenetriamine/NO (DETA/NO)
  • GLO/NO
  • JS-K
  • Methylamine hexamethylene methylamine/NO (MAHMA/NO)
  • PROLI/NO
  • Spermine/NO (SPER/NO)
  • V-PYRRO/NO
  • Unsorted: Cimlanod
  • FK-409
  • FR144220
  • FR146881
  • N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide
Enzyme
(inhibitors)
NOS
nNOS
iNOS
  • 1-Amino-2-hydroxyguanidine
  • 2-Ethylaminoguanidine
  • 2-Iminopiperidine
  • 1400W
  • AEITU
  • Aminoguanidine (pimagedine)
  • AMT
  • AR-C 102222
  • BYK-191023
  • Canavanine
  • Cindunistat (SD-6010)
  • EITU
  • IPTU
  • MITU
  • N5-(1-Iminoethyl)-L-ornithine (L-NIO)
  • N6-(1-Iminoethyl)-L-lysine (L-NIL)
  • Nω-Methyl-L-arginine (L-NMA)
  • Ronopterin (VAS-203)
  • TRIM
eNOS
Unsorted
Arginase
CAMK
  • Calmidazolium
  • W-7
Others
  • Precursors: L-Arginine
  • Nω-Hydroxy-L-arginine (NOHA)
See also: Receptor/signaling modulators


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