VTI1A

Protein-coding gene in the species Homo sapiens
VTI1A
Identifiers
AliasesVTI1A, MMDS3, MVti1, VTI1RP2, Vti1-rp2, vesicle transport through interaction with t-SNAREs 1A
External IDsOMIM: 614316; MGI: 1855699; HomoloGene: 39963; GeneCards: VTI1A; OMA:VTI1A - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for VTI1A
Genomic location for VTI1A
Band10q25.2Start112,446,998 bp[1]
End112,818,744 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for VTI1A
Genomic location for VTI1A
Band19|19 D2Start55,304,727 bp[2]
End55,615,741 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • Achilles tendon

  • pancreatic ductal cell

  • buccal mucosa cell

  • testicle

  • monocyte

  • bone marrow cells

  • corpus callosum

  • epithelium of colon

  • blood
Top expressed in
  • Rostral migratory stream

  • granulocyte

  • superior frontal gyrus

  • right kidney

  • genital tubercle

  • dentate gyrus of hippocampal formation granule cell

  • lumbar subsegment of spinal cord

  • tail of embryo

  • medial dorsal nucleus

  • proximal tubule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • SNAP receptor activity
  • protein binding
  • SNARE binding
Cellular component
  • integral component of membrane
  • endosome
  • Golgi apparatus
  • membrane
  • synaptic vesicle
  • autophagosome
  • neuronal cell body
  • SNARE complex
  • perinuclear region of cytoplasm
  • neuron projection terminus
  • cytoplasmic vesicle
  • clathrin-coated vesicle
  • trans-Golgi network membrane
  • ER to Golgi transport vesicle membrane
  • cytosol
  • Golgi membrane
  • late endosome membrane
  • endoplasmic reticulum membrane
  • intracellular membrane-bounded organelle
Biological process
  • voluntary musculoskeletal movement
  • autophagy
  • retrograde transport, endosome to Golgi
  • protein transport
  • intracellular protein transport
  • Golgi ribbon formation
  • vesicle-mediated transport
  • Golgi to vacuole transport
  • vesicle fusion with Golgi apparatus
  • intra-Golgi vesicle-mediated transport
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • protein targeting to vacuole
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

143187

53611

Ensembl

ENSG00000151532

ENSMUSG00000024983

UniProt

Q96AJ9

O89116

RefSeq (mRNA)
NM_145206
NM_001318203
NM_001318205
NM_001365710
NM_001365711

NM_001365712
NM_001365713
NM_001365714

NM_001293685
NM_001293686
NM_016862
NM_001360431
NM_001360432

RefSeq (protein)
NP_001305132
NP_001305134
NP_660207
NP_001352639
NP_001352640

NP_001352641
NP_001352642
NP_001352643

NP_001280614
NP_001280615
NP_058558
NP_001347360
NP_001347361

Location (UCSC)Chr 10: 112.45 – 112.82 MbChr 19: 55.3 – 55.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vesicle transport through interaction with t-SNAREs homolog 1A is a protein that in humans is encoded by the VTI1A gene.[5][6]

The protein encoded by the VTI1A gene is a vesicular-SNARE (v-SNARE) protein which is located in the membranes of target vesicle compartments.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151532 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024983 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: vesicle transport through interaction with t-SNAREs homolog 1A (yeast)".
  6. ^ Fischer von Mollard G, Stevens TH (January 1998). "A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways". J. Biol. Chem. 273 (5): 2624–30. doi:10.1074/jbc.273.5.2624. PMID 9446565.
  7. ^ "VTI1A vesicle transport through interaction with t-SNAREs 1A [Homo sapiens (Human)] - Gene - NCBI".

Further reading

  • Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene Variants Associated With Ischemic Stroke: The Cardiovascular Health Study". Stroke. 40 (2): 363–8. doi:10.1161/STROKEAHA.108.521328. PMC 2881155. PMID 19023099.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Grupe A, Li Y, Rowland C, et al. (2006). "A Scan of Chromosome 10 Identifies a Novel Locus Showing Strong Association with Late-Onset Alzheimer Disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
  • Mallard F, Tang BL, Galli T, et al. (2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". J. Cell Biol. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.
  • Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of Gene Variants with Incident Myocardial Infarction in the Cardiovascular Health Study". Arterioscler. Thromb. Vasc. Biol. 28 (1): 173–9. doi:10.1161/ATVBAHA.107.153981. PMC 2636623. PMID 17975119.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Flowerdew SE, Burgoyne RD (2009). "A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels". Biochem. J. 418 (3): 529–40. doi:10.1042/BJ20081736. PMC 2650881. PMID 19138172.
  • Tai G, Lu L, Wang TL, et al. (2004). "Participation of the Syntaxin 5/Ykt6/GS28/GS15 SNARE Complex in Transport from the Early/Recycling Endosome to the Trans-Golgi Network". Mol. Biol. Cell. 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.
  • Antonin W, Holroyd C, Fasshauer D, et al. (2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.
  • v
  • t
  • e
  • 2nps: Crystal Structure of the Early Endosomal SNARE Complex
    2nps: Crystal Structure of the Early Endosomal SNARE Complex
  • 1vcs: Solution Structure of RSGI RUH-009, an N-Terminal Domain of Vti1a [Mus musculus]
    1vcs: Solution Structure of RSGI RUH-009, an N-Terminal Domain of Vti1a [Mus musculus]
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