XRCC4

PDB prikaz baziran na 1fu1.

Dostupne strukture

1fu1

Identifikatori

Simboli

XRCC4;

Vanjski ID

OMIM: 194363 MGI: 1333799 HomoloGene: 2555 GeneCards: XRCC4 Gene

Ontologija gena
Molekularna funkcija	• DNK vezivanje • proteinsko vezivanje • proteinsko C-terminusno vezivanje • aktivnost ligaze
Celularna komponenta	• kondenzovani hromozom • nukleus • nukleoplazma • citozol • DNK zavisna proteinska kinaza - DNK ligaza 4 kompleks • DNK ligaza IV kompleks
Biološki proces	• in utero embrionski razvoj • pro-B ćelijska diferencijacija • popravka DNK • popravka dvolančanih prekida • popravka dvolančanih prekida nehomolognim spajanjem krajeva

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

7518

108138

Ensembl

ENSG00000152422

ENSMUSG00000021615

UniProt

Q13426

Q924T3

RefSeq (mRNA)

NM_003401.3

NM_028012.4

RefSeq (protein)

NP_003392.1

NP_082288.1

Lokacija (UCSC)

Chr 5:
82.37 - 82.65 Mb

Chr 13:
89.91 - 90.23 Mb

PubMed pretraga

[1]

[2]

Protein popravke DNK XRCC4 je kod ljudi kodiran XRCC4 genom.^[1]^[2]^[3]

Interakcije

XRCC4 formira interakcije sa LIG4^[4]^[5] i XLF protein.^[4]

Reference

^ Giaccia AJ, Denko N, MacLaren R, Mirman D, Waldren C, Hart I, Stamato TD (1990). „Human chromosome 5 complements the DNA double-strand break-repair deficiency and gamma-ray sensitivity of the XR-1 hamster variant”. Am J Hum Genet. 47 (3): 459—69. PMC 1683886 . PMID 1697445.
^ Otevrel T, Stamato TD (1995). „Regional localization of the XRCC4 human radiation repair gene”. Genomics. 27 (1): 211—4. PMID 7665175. doi:10.1006/geno.1995.1029.
^ „Entrez Gene: XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4”.
^ ^а ^б Deshpande, Rajashree A; Wilson Thomas E (2007). „Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4”. DNA Repair (Amst.). Netherlands. 6 (10): 1507—16. ISSN 1568-7864. PMC 2064958 . PMID 17567543. doi:10.1016/j.dnarep.2007.04.014.
^ Sibanda, B L; et al. (2001). „Crystal structure of an Xrcc4-DNA ligase IV complex”. Nat. Struct. Biol. United States. 8 (12): 1015—9. ISSN 1072-8368. PMID 11702069. doi:10.1038/nsb725.

Literatura

Lieber MR (1999). „The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes.”. Genes Cells. 4 (2): 77—85. PMID 10320474. doi:10.1046/j.1365-2443.1999.00245.x.
Li Z; Otevrel T; Gao Y; et al. (1996). „The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination.”. Cell. 83 (7): 1079—89. PMID 8548796. doi:10.1016/0092-8674(95)90135-3.
Grawunder U; Wilm M; Wu X; et al. (1997). „Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells.”. Nature. 388 (6641): 492—5. PMID 9242410. doi:10.1038/41358.
Critchlow SE, Bowater RP, Jackson SP (1997). „Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV.”. Curr. Biol. 7 (8): 588—98. PMID 9259561. doi:10.1016/S0960-9822(06)00258-2.
Mizuta R, Cheng HL, Gao Y, Alt FW (1998). „Molecular genetic characterization of XRCC4 function.”. Int. Immunol. 9 (10): 1607—13. PMID 9352367. doi:10.1093/intimm/9.10.1607.
Leber R, Wise TW, Mizuta R, Meek K (1998). „The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase.”. J. Biol. Chem. 273 (3): 1794—801. PMID 9430729. doi:10.1074/jbc.273.3.1794.
Gao Y; Sun Y; Frank KM; et al. (1999). „A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis.”. Cell. 95 (7): 891—902. PMID 9875844. doi:10.1016/S0092-8674(00)81714-6.
Modesti M, Hesse JE, Gellert M (1999). „DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity.”. EMBO J. 18 (7): 2008—18. PMC 1171285 . PMID 10202163. doi:10.1093/emboj/18.7.2008.
Nick McElhinny SA, Snowden CM, McCarville J, Ramsden DA (2000). „Ku recruits the XRCC4-ligase IV complex to DNA ends.”. Mol. Cell. Biol. 20 (9): 2996—3003. PMC 85565 . PMID 10757784. doi:10.1128/MCB.20.9.2996-3003.2000.
Gao Y; Ferguson DO; Xie W; et al. (2000). „Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development.”. Nature. 404 (6780): 897—900. PMID 10786799. doi:10.1038/35009138.
Chen L, Trujillo K, Sung P, Tomkinson AE (2000). „Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase.”. J. Biol. Chem. 275 (34): 26196—205. PMID 10854421. doi:10.1074/jbc.M000491200.
Lee KJ, Huang J, Takeda Y, Dynan WS (2000). „DNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining system.”. J. Biol. Chem. 275 (44): 34787—96. PMID 10945980. doi:10.1074/jbc.M004011200.
Ford BN; Ruttan CC; Kyle VL; et al. (2000). „Identification of single nucleotide polymorphisms in human DNA repair genes.”. Carcinogenesis. 21 (11): 1977—81. PMID 11062157. doi:10.1093/carcin/21.11.1977.
Sibanda BL; Critchlow SE; Begun J; et al. (2002). „Crystal structure of an Xrcc4-DNA ligase IV complex.”. Nat. Struct. Biol. 8 (12): 1015—9. PMID 11702069. doi:10.1038/nsb725.
Lee KJ; Dong X; Wang J; et al. (2002). „Identification of human autoantibodies to the DNA ligase IV/XRCC4 complex and mapping of an autoimmune epitope to a potential regulatory region.”. J. Immunol. 169 (6): 3413—21. PMID 12218164.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Hsu HL, Yannone SM, Chen DJ (2003). „Defining interactions between DNA-PK and ligase IV/XRCC4.”. DNA Repair (Amst.). 1 (3): 225—35. PMID 12509254. doi:10.1016/S1568-7864(01)00018-0.